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PHOSGENATION CHEMISTRY

ACCESS TO A WIDE RANGE OF PRODUCTS

Phosgene is a powerful reagent allowing in an effective way access to key reactives such as chloroformates, acid chlorides and carbamoyl chlorides. This process permits the clean and successful construction of isocyanates, carbonates, carbamides or ureas.

The hazardous potential of using phosgene is well known. With this in mind, our new phosgenation plant has been constructed to the highest safety standards, guaranteeing safe and environmental friendly working conditions.

By using phosgene we are able to offer you both quality and value for money. A direct reaction with phosgene is often shorter and more cost-effective than alternative methods or workarounds, thereby reducing waste and energy consumption. In contrast to other carbonylating agents such as di- and triphosgene, traces of phosgene in the API is not an issue due to its fast rate of hydrolysis.

Phosgene chemistry opens a broad pallet of chemistries which you cannot afford to ignore during development of new chemical entities.

Phosgenation Products

Phosgenation allows the manufacturing of a large variety of products containing structural units often applied in the polymer- and pharmaceutical industries. Isocyanates, N-carboxy anhydrides, carbodiimides and many others can be efficiently formed by phosgenation of amines, alcohols, acids, thiols or even aldehydes.

Valsynthese now provides custom synthesis of these derivatives from process research & development to large scale manufacturing.

Possible Targets: BOC-Anhydride, Dimethyl-carbonate, Menthyl chloroformate, Fmoc-chloride or Adoc-chloride. Please contact us for more information.

Phosgenation Plant

The phosgenation plant is located in a dedicated compartment, which forms an annex to an existing multipurpose plant. The size of the phosgenation plant is designed in a way that the subsequent work-up fits to the existing 4000 L multipurpose reactors. Phosgene is generated continuously and transferred directly into the reactor without any storage to avoid any accumulation. The separate compartment allows easy monitoring of the production area and acts as a second barrier to the environment. The multipurpose character of this plant allows us to perform other hazardous reactions such as chlorination and azide chemistry.

Material Flow
Material Flow